A MESAS report, published as part of NHS Health Scotland’s commitment to monitoring and evaluating Scotland’s Alcohol Strategy, assesses population levels of alcohol consumption based on retail sales data in Central Scotland, North West and North East England, comparing with levels of alcohol-related mortality. The report shows that in 2011, 23% more alcohol was sold per capita in Scotland (9.0L) than in England & Wales (7.3L). At regional level, per capita sales were 13% and 12% higher in Central Scotland (9.0L) than in NE England (7.9L) and NW England (8.0L), respectively. Compared with England & Wales, per capita sales in NE England and NW England were 8% and 10% higher, respectively. Consistent with national comparisons, spirits accounted for a much higher market share in Central Scotland than the regions in Northern England. In 2011, alcohol-related mortality was 80% higher in Scotland than in England & Wales. At regional level, alcohol-related mortality in Central Scotland was 14% higher than the Scotland average, 67% higher than NE England, and 47% higher than NW England. Alcohol-related mortality rates in NE and NW England were 23% and 40% higher than the England & Wales average, respectively. Regional comparisons of alcohol-related mortality and previously unavailable alcohol retail sales data in Scotland and Northern England show that alcohol-related mortality is generally higher in areas with higher per capita alcohol consumption levels. However, for Central Scotland the relationship is more complicated; the region has a higher level of alcohol related mortality than Scotland as a whole despite similar consumption levels.