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A meta-analysis of alcohol intake and risk of bladder cancer

Epidemiologic studies have reported conflicting results relating alcohol intake to bladder cancer
risk. A meta-analysis of cohort and case-control studies was conducted to pool the risk estimates of
the association between alcohol intake and bladder cancer.
Eligible studies were retrieved via both computer searches and review of references. The authors
analysed abstracted data with random effects models to obtain the summary risk estimates. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for a series of exposure levels. Nineteen studies met the inclusion criteria of the meta-analysis.
No association with bladder cancer was observed in either overall alcohol intake group (OR = 1.00, 95% CI 0.89-1.10) or subgroups stratified by sex, study design, geographical region, or smoking status. However, in the analysis by specific beverages, both beer (OR = 0.86, 95% CI 0.76-0.96) and wine (OR = 0.85, 95% CI 0.71-1.00) consumption exhibited a negative doseresponse relationship with bladder cancer.
The overall current literature on alcohol consumption and the risk of bladder cancer suggested no
association, while the consumption of beer and wine was associated with reduced risk of bladder cancer. The authors suggest that further efforts should be made to confirm these findings and clarify the underlying biological mechanisms.
Source: A meta-analysis of alcohol intake and risk of bladder cancer. Mao QQ; Lin YW; Zheng XY; Qin J; Yang K; Xie LP Cancer Causes and Control. Vol 21, No 11, 2010, pp1843-185
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