Researchers evaluated whether alcohol is associated in the development of breast cancer among women with a BRCA1 or BRCA2 mutation. Information regarding baseline daily alcohol consumption was abstracted from a research questionnaire for 3,067 BRCA mutation carriers enrolled in a prospective cohort study. The women were followed biennially until the date of the last follow-up questionnaire, date of breast cancer diagnosis, date of prophylactic bilateral mastectomy, or date of death. Cox proportional hazards models were used to estimate relative risks (RRs) and 95 % confidence intervals (CIs) for invasive breast cancer associated with alcohol consumed at or prior to completion of the baseline questionnaire.
After a mean of 5.4 years of follow-up, 259 incident cases of primary invasive breast cancer had occurred. Compared with non-users, the adjusted RRs were 1.06 (95 % CI 0.78–1.44) for ever use and 1.08 (0.79–1.47) for current alcohol use. For women in the highest versus lowest quintile of cumulative alcohol consumption, the RR was 0.94 (95 % CI 0.63–1.40; P trend = 0.65). The study findings therefore suggest that alcohol consumption is not a risk factor for breast cancer among women with a BRCA1 or BRCA2 mutation.
Source: Prospective evaluation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. C Cybulski, J Lubinski, T Huzarski, HT Lynch, SA Randall, SL Neuhausen, L Senter, S Friedman, P Ainsworth, C Singer, WD Foulkes, SA Narod, P Sun, J Kotsopoulos. Breast Cancer Research and Treatment. June 2015, Volume 151, Issue 2, pp 435-441.