Page last updated: June 3, 2016
Dose-dependent associations between wine drinking and breast cancer risk - meta-analysis findings

A study published in the Asian Pacific Journal of Cancer Prevention investigated the potential association between wine and breast cancer risk.

The research quantitatively assessed associations by conducting a meta-analysis based on evidence from observational studies. Searches were performed in PubMed, EmBase and the Cochrane Library to identify studies examining the effect of wine drinking on breast cancer incidence. A total of twenty-six studies (eight case-control and eighteen cohort studies) involving 21,149 cases were included in the metaanalysis. The relative risk (RR) or odds ratio (OR) were used to measure any such association. The analysis was further stratified by confounding factors that could influence the results.

The study demonstrated that wine drinking was associated with breast cancer risk. A 36% increase in breast cancer risk was observed across overall studies based on the highest versus lowest model, with a combined RR of 1.0059 (95%CI 0.97-1.05) in doseresponse analysis. However, 5 g/d ethanol from wine seemed to have protective value from the non-linear model. The findings indicate that wine drinking is associated with breast cancer risk in a dose-dependent manner. High consumption of wine contributes to breast cancer risk with protection exerted by low doses.

The authors suggest that further investigations are needed for clarification.

Source: Dose-dependent associations between wine drinking and breast cancer risk - meta-analysis findings. Chen JY; Zhu HC; Guo Q; Shu Z; Bao XH; Sun F; Qin Q; Yang X; Zhang C; Cheng HY; Sun XC. Asian Pacific Journal of Cancer Prevention. Vol 17, No 3, 2016, pp1221-1233.

 
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