There have been inconsistent results with respect to the correlation between consumption of wine and the development of colorectal cancer (CRC). A team of researchers carried out a meta-analysis to investigate this issue.
A literature search of Embase and Pubmed from inception till 28 February 2017 was carried out to identify relevant observational studies. Eight casecontrol and nine cohort studies were identified, involving 12,110 CRC cases. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated using a random-effects model.
The meta-analysis showed that wine drinking was not associated with any greater risk for CRC (SRR=0.99, 95% CI: 0.89-1.10; P<0.001) compared with non-drinkers. The subgroup analyses indicated that null associations were observed in men and women for colon and rectal cancer. Neither light to moderate (<2 drinks/day; SRR=0.93, 95% CI: 0.80-1.08, I=69.2%) nor heavy (≥2 drinks/day; SRR=1.00, 95% CI: 0.86-1.16, I=39.9%) consumption of wine was associated statistically with CRC risk. This meta-analysis suggests that any wine consumption was not associated with the risk of CRC. Null associations were shown in men and women for colon and rectal cancer.
Source: Wine consumption and colorectal cancer risk: a meta-analysis of observational studies. Xu W, Fan H, Han Z, Liu Y, Wang Y, Ge Z. Eur J Cancer Prev. 2018 Sep 21. doi.org/10.1097/CEJ.0000000000000444.