Page last updated: August 15, 2017
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium

Recent studies have reported an association between heavy alcohol drinking and gastric cancer risk, but the issue is still open to discussion and quantification.

A team of researchers investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project”, a pooled analysis of casecontrol studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. Summary odds-ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated.

Compared with abstainers, drinkers of up to 4 drinks/ day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08-1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29- 1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35-2.58) as compared to current smokers (OR 1.14, 95% CI 0.93-1.40).

Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11-2.34) than in non-cardia (OR 1.28, 95% CI 1.13-1.45) gastric cancers, and in intestinal-type (OR 1.54, 95% CI 1.20- 1.97) than in diffuse-type (OR 1.29, 95% CI 1.05-1.58) cancers. The association was similar in strata of H. pylori infected (OR=1.52, 95% CI 1.16-2.00) and noninfected subjects (OR=1.69, 95% CI 0.95-3.01).

This collaborative pooled-analysis provides definite, more precise quantitative evidence than previously available of an association between very heavy alcohol drinking (over 4 drinks a day) and gastric cancer risk but no association with up to 4 drinks a day.

Source: Consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium. Rota M, Pelucchi C, Bertuccio P, Matsuo K, et al. Int J Cancer. 2017 Jul 18. doi: 10.1002/ijc.30891.

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