Authors of a study investigating association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk conducted a meta-analysis of available data.
20 case-control and 4 cohort studies were identified as suitable for inclusion, including a total of 5500 cases. The study results indicate that the relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light ( < / = 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (>/= 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day.
The authors conclude that this meta-analysis provides definite evidence of an absence of association between light and moderate alcohol drinking and esophageal and gastric cardia adenocarcinoma risk.
Source: A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk Tramacere I; Pelucchi C; Bagnardi V; Rota M; Scotti L; Islami F; Corrao G; Boffetta P; La Vecchia C; Negri E . Annals of Oncology Vol 23, No 2, 2012, pp287-297