The role of alcohol intake in influencing longitudinal trajectories of adiponectin is unclear. This study explored the association between alcohol intake and changes in circulating levels of adiponectin over repeat measures.
The prospective cohort study included data from 2,855 men and women (74% men with a mean age of 50 years at baseline) drawn from the Whitehall II study. Data from study phases 3 (1991-1993), 5 (1997-1999) and 7 (2002-2004) were used.
Adiponectin serum concentrations (ng/mL) were measured and alcohol intake was defined in terms of number of UK units (1 unit = 8g ethanol) consumed in the previous 7 days on three occasions. Cross-sectional associations between alcohol and adiponectin levels were calculated using linear regression. A bivariate dual change score model was used to estimate the effect of alcohol intake on upcoming change in adiponectin. Models were adjusted for age, sex, ethnicity and smoking status.
Alcohol intake is not associated with changes in circulating adiponectin levels in this cohort. This finding provides evidence that adiponectin levels are unlikely to mediate the relationship between moderate alcohol consumption and reduced risk of type 2 diabetes.
Source: The role of alcohol consumption in regulating circulating levels of adiponectin: a prospective cohort study. Bell S, Britton A. J Clin Endocrinol Metab. 2015 May 22.