Several studies have been proposed to investigate the association between alcohol consumption and risk of Barrett’s esophagus (BE), but as of yet, no quantitative summary of the literature to clarify the relationship between them.
In an analysis, twenty eligible cohort studies involving 42,925 participants were identified. Combined relative risk (RR) ratios for the highest versus lowest alcohol consumption levels were calculated. The alcohol dose-response analysis was performed to investigate the association between the increment consumption of 10 g/d alcohol and the risk of developing BE.
A combined RR of 0.98 (0.62–1.34) was found when comparing highest vs. lowest alcohol consumption levels for BE. An inverse association – ie a protective effect between alcohol and incidence of BE (RR 0.51; 95% CI: 0.055–0.96) was demonstrated in women. Asian drinkers had a relative higher risk of BE (RR 1.34; 95% CI: 1.11–1.56) compared with Western drinkers. The authors conclude that overall alcohol consumption was not associated with increased BE incidence. The limited data available on alcohol consumption supports a tentative inversion of alcohol consumption with BE risk in women, while Asian drinkers tend to have a higher risk of BE.
Source: Alcohol consumption and the risk of Barrett’s esophagus: a comprehensive meta-analysis. Lin-Lin Ren, Ting-Ting Yan, Zhen-Hua Wang, Zhao-Lian Bian, Fan Yang, Jie Hong, Hao-Yan Chen & Jing-Yuan Fang. Nature. com Scientific Reports 5, Article number: 16048 (2015). Published online:06 November 2015, open access.