Page last updated: Tuesday, November 18, 2008
Grape-derived polyphenolics may be effective in Alzheimer's Disease prevention
A new study suggests that a red grape seed extract could help protect against memory loss due to Alzheimer’s disease, following research in mice.

Rodents prone to developing Alzheimer’s-like brain changes showed better cognitive function at 11 months of age - when they would have been expected to already have some memory impairment - if they were given the grape seed polyphenolic extract in their drinking water, Dr. Giulio Maria Pasinetti of the Mount Sinai School of Medicine and colleagues found.

The mice in the study received levels of polyphenols equivalent to what a person would consume with a daily glass or two of red wine.

While the health benefits of moderate red wine consumption are fairly clear, Pasinetti noted in an interview, “moderate consumption of alcohol in the form of red wine might have potential complications for people with maybe metabolic disorders or cardiovascular disorders.”

Pasinetti and his team investigated whether an extract of red grape seeds might prevent the progress of the disease in mice.

Mice received an amount equivalent to 1 gram of polyphenolic extract daily for humans, or plain water. After five months of treatment, the grape seed extract-fed mice had 30 to 50% less clumping of amyloid-beta protein in their brains.

Amyloid-beta protein clumping is a key step in the formation of the plaques and tangles within the brain seen in Alzheimer’s patients, so preventing it could conceivably help slow brain degeneration.

Animals treated with the extract also performed significantly better on a standard test of spatial learning memory than rodents who didn’t receive it. But the extract did not improve maze performance in control mice, suggesting that it improved cognitive function in the Alzheimer’s prone rodents by reducing brain damage due to plaque formation.

Pasinetti and his colleagues are now planning clinical trials to determine if polyphenolic extract could prevent or even treat Alzheimer’s in humans.

Source: The Journal of Neuroscience, June 18, 2008. Jun Wang, Lap Ho, Wei Zhao, Kenjiro Ono, Clark Rosensweig, Linghong Chen, Nelson Humala, David B. Teplow, and Giulio M. Pasinetti

no website link
All text and images © 2003 Alcohol In Moderation.