A Mediterranean diet (MD) is the most relevant nutritional aspect of the multisecular Mediterranean civilisation which includes wine as an element of health and wellbeing when consumed with moderation. Mediterranean meals provide food micronutrients which include polyphenols, especially resveratrol from grape and red wine. MD, also called Cretan diet,
has been proven to prevent diseases including cardiovascular pathologies, cancer, and to prevent aging. The grape skin contains the highest concentration of resveratrol (RSV) and so red wine is the most concentrated food source of RSV found
in the human diet.
A review examines what affect RSV might have during the aging process; obtained from recent data of clinical trials, preclinical studies and cell culture approach; especially RSV protecting effect on brain aging of elderly; its role on the microglial cells playing a central role in the neuroinflammation; and in its anti-inflammatory effects on ocular diseases.
Source: How efficient is resveratrol as an antioxidant of the Mediterranean Diet, towards alterations during the aging process? Silva P, Sureda A, Tur JA, Andreoletti P, Cherkaoui-Malki M, Latruffe N. Free Radic Res. 2019