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Supplementation with red wine extract increases insulin sensitivity and peripheral blood mononuclear Sirt1 expression in nondiabetic humans

Research published in the journal Nutrients, investigated the effects of dietary supplementation with a nonalcoholic red wine extract (RWE), which includes resveratrol and polyphenols, on insulin sensitivity and Sirt1 expression in nondiabetic humans.
In the study, twelve subjects received supplementation with RWE, including 19.2 mg resveratrol and 136 mg polyphenols, daily for 8 weeks. After 8 weeks, metabolic parameters, including glucose/lipid metabolism and inflammatory markers, were evaluated. mRNA expression of Sirt1 was evaluated in isolated peripheral blood mononuclear cells (PBMNCs). Additionally, Sirt1 and phosphorylated AMP-activated kinase (p-AMPK) expression were evaluated in cultured human monocytes (THP-1 cells).
Supplementation with RWE for 8 weeks decreased the homeostasis model assessment for insulin resistance (HOMA-IR), which indicates an increase in insulin sensitivity. Serum low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG) and interleukin-6 (IL-6) were significantly decreased by RWE supplementation for 8 weeks. Additionally, Sirt1 mRNA expression in isolated PBMNCs was significantly increased after 8 weeks of RWE supplementation. Moreover, the rate of increase in Sirt1 expression was positively correlated with the rate of change in HOMA-IR.
The study concludes that supplementation with Red Wine Extract (RWE) improved metabolism, such as insulin sensitivity, lipid profile and inflammation, in humans. Additionally, RWE supplementation induced an increase in Sirt1 expression in peripheral blood mononuclear cells, which may be associated with an improvement in insulin sensitivity.
Source: Kitada M, Ogura Y, Monno I, Koya D. Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans. Nutrients. 2020 Oct 12;12(10):3108.


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