Researchers conducted a genomewide association study (GWAS) for ‘maximum number of alcoholic drinks consumed in a 24-hour period’ (MaxDrinks), in 2 independent samples comprised of over 9,500 subjects, following up on the GWAS samples for alcohol dependence in European Americans (EAs) and African Americans (AAs).
Data was from GWAS samples (Yale-UPenn) recruited for studies of the genetics of drug or AD, and a publicly available sample: the Study of Addiction: Genetics and Environment (SAGE). Genomewide association analysis was performed for ~890,000 single nucleotide polymorphisms (SNPs) using linear association random effects models. EAs and AAs were separately analysed.
The results confirmed significant associations of the well-known functional loci at ADH1B with MaxDrinks in EAs and AAs. The region of significant association on chromosome 4 was extended to LOC100507053 in AAs but not EAs. The researchers also identified potentially novel significant common SNPs for MaxDrinks in EAs in the Yale-UPenn sample: rs1799876 at SERPINC1 on chromosome 1 and rs2309169 close to ANKRD36 on chromosome 2. After adjusting for the peak SNP rs1229984 on ADH1B, rs1799876 was nearly significant and rs2309169 remained highly significant.
The results provide further support that ADH1B modulates alcohol consumption. Future replications of potential novel loci are warranted, the authors suggest.
Source: Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans Ke Xu, Henry R. Kranzler, Richard Sherva, Carolyn E. Sartor, Laura Almasy, Ryan Koesterer, Hongyu Zhao, Lindsay A. Farrer and Joel Gelernter. Article first published online: 3 Jun 2015.