There are few reports of associations between alcohol consumption and risk of chronic kidney disease (CKD). To investigate this further, a research group studied 5,476 participants aged 28–75 years in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, a prospective population-based cohort, who were free of CKD at baseline (1997/1998). Alcohol consumption was self-reported on a questionnaire validated against serum high-density lipoprotein cholesterol.
The primary outcome was de novo CKD defined as a combination of a creatinine–cystatin C–based estimated glomerular filtration rate (eGFR) under 60 ml/min per 1.73 m2 and/or the mean of two consecutive 24-h urinary albumin excretions over 30 mg. During four serial follow-up examinations (median 10.2 years until February 2012), 903 participants developed CKD. Compared with those abstaining from alcohol, the multivariable-adjusted hazard ratios (95% confidence interval) for CKD risk were 0.85 (0.69–1.04) for occasional (under 10 g/week), 0.82 (0.69–0.98) for light (10–69.9 g/week), 0.71 (0.58–0.88) for moderate (70–210 g/week), and 0.60 (0.42–0.86) for heavier (over 210 g/week) alcohol consumers (significant trend). Similar inverse associations for alcohol consumption were found when CKD was defined as eGFR <60 ml/min per 1.73 m2 or as 24-h urinary albumin excretion over 30 mg. Thus, in this population-based cohort, alcohol consumption was inversely associated with the risk of developing CKD.
Source: The researchers conclude that alcohol consumption is inversely associated with the risk of developing chronic kidney disease. Sarah H Koning, Ron T Gansevoort, Kenneth J Mukamal, Eric B Rimm, Stephan J L Bakker, Michel M Joosten and REVEND Study Group. Kidney International, (14 January 2015).