Page last updated: Tuesday, November 18, 2008
Alcohol use and Parkinsons disease.
Parkinsons disease is a common and disabling condition, however the causes of most cases remain unknown. The prevalence and incidence of Parkinsons disease increase with age and is the most consistently accepted risk factor for the disease. For all ages, the prevalence and incidence of Parkinsons disease is higher among men than women.

This study by Paganini-Hill A, forming part of a prospective cohort study of 13,979 residents of Leisure World Laguna Hills, a retirement community in southern California, aimed at finding aetiological clues for Parkinsons disease. The study population was a predominantly white, well-educated, stable, health conscious, upper middle class community. A total of 395 cases of Parkinsons disease were identified between 1981(when the first questionnaire was mailed) and 1998. For each case 6 controls were matched on sex, age, vital status and, if dead, date of death. Baseline characteristics of the 395 cases and 2320 controls were analysed as potential risk factors.

A lowered risk for Parkinsons disease was found among smokers, hyper-tensives, coffee users and alcohol drinkers while the disease risk was elevated among those with 3 or more children and with a high intake of total vitamin A and dietary vitamin C. The multivariate OR was 0.42 (95% CI 0.22-0.80) for current smokers of one pack or more daily, 0.71 (95% CI 0.52-0.95) for those drinking at least two cups of coffee daily and 0.77 (95% CI 0.58-1.03) for those having at least two alcoholic drinks per day. Risk increased with increasing number of children (P = 0.0003 for trend).

The results suggest that several environmental factors may be associated with the development of PD and corroborate a multifactorial aetiology of PD. As with other studies, the results indicate that alcohol use and coffee consumption are inversely associated with PD risk. Source. Paganini-Hill A. Risk factors for Parkinsons disease: the Leisure World Cohort Study. Neuroepidemiology 20 (2001) 118-124.

no website link
All text and images © 2003 Alcohol In Moderation.