Page last updated: August 16, 2013
Alcohol intake and risk of Parkinson’s disease

The association of alcohol intake with risk of Parkinson’s disease remains unclear. Researchers identified pertinent studies in EMBASE. 32 articles involving 677,550 subjects (9994 cases) were selected. The smoking-adjusted risk of Parkinson’s disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies.

A significant association was found with beer (0.59; 95% CI, 0.39-0.90) and less with wine and spirits, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson’s disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (P-for nonlinearity=0.85) dose-response manner. Therefore, alcohol intake, especially beer, might be inversely associated with risk of Parkinson’s disease, the authors conclude.

Source: Alcohol intake and risk of Parkinson’s disease: a meta-analysis of observational studies Zhang DF; Jiang H; Xie JX. Movement Disorders. Vol 29, No 6, 2014, pp819- 822.

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