The association of alcohol intake with risk of Parkinson’s disease remains unclear. Researchers identified pertinent studies in EMBASE. 32 articles involving 677,550 subjects (9994 cases) were selected. The smoking-adjusted risk of Parkinson’s disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies.
A significant association was found with beer (0.59; 95% CI, 0.39-0.90) and less with wine and spirits, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson’s disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (P-for nonlinearity=0.85) dose-response manner. Therefore, alcohol intake, especially beer, might be inversely associated with risk of Parkinson’s disease, the authors conclude.
Source: Alcohol intake and risk of Parkinson’s disease: a meta-analysis of observational studies Zhang DF; Jiang H; Xie JX. Movement Disorders. Vol 29, No 6, 2014, pp819- 822.