Page last updated:November 26, 2013
Relationship between alcohol intake and lipid accumulation product in middle-aged men – moderate drinking more protective for those who smoke and don’t exercise

Lipid accumulation product (LAP), defined as a product of waist circumference and triglycerides, has recently been proposed as a predictor of cardiovascular disease and diabetes mellitus. The purpose of a study led by Ichiro Wakabayashi was to determine whether and how LAP is associated with alcohol drinking.

21,378 men aged 35–60 years were included in the study and they were divided by alcohol intake into non-, light (<22 g ethanol/day), heavy (≥22 and <44 g ethanol/day) and very heavy (≥44 g ethanol/day) drinkers. Relationships between alcohol intake and LAP were analysed by using multivariate analyses with adjustment for age, smoking and habitual exercise.

LAP levels in light drinkers and very heavy drinkers were significantly lower and higher, respectively, than the level in non-drinkers, and the levels were comparable in non- and heavy drinkers (non-drinkers, 1.335 ± 0.005; light drinkers, 1.290 ± 0.009; heavy drinkers, 1.348 ± 0.005 and very heavy drinkers, 1.414 ± 0.006).

The inverse association of alcohol intake with a reduction of lipid accumulation was more prominent in moderate drinkers and among smokers and subjects without regular exercise than in non-smokers and subjects with regular exercise, respectively, while the positive association of alcohol with LAP was associated with heavy drinking and was more prominent in non-smokers than in smokers.

The odds ratio for hyperglycemia of subjects with vs. subjects without high LAP was significantly higher than a reference level of 1.00, and this association was not different among the four alcohol groups.

The authors conclude that there is a J-shaped relationship between alcohol intake and LAP, which is confounded by smoking and habitual exercise.

Source: Relationship Between Alcohol Intake and Lipid Accumulation Product in Middle-aged
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