A study was conducted to investigate and quantify the potential dose-response association between alcohol consumption and risk of coronary artery disease (CAD).
The PubMed database from inception to March 2015 was searched and the reference list of relevant articles was reviewed to identify prospective studies assessing the association between alcohol consumption and risk of CAD.
The meta-analysis included 18 prospective studies, with a total of 214,340 participants and 7,756 CAD cases. The pooled adjusted RRs were 0.62 (95% confidence interval [CI] 0.56-0.68) for highest alcohol consumption amount versus lowest amount. In a dose response analysis, the authors observed a nonlinear association between alcohol consumption and risk of CAD (P for nonlinearity < 0.00). Compared with non-drinkers, the RRs (95% CI) of CAD across levels of alcohol consumption were 0.75 (0.70-0.80) for 12 g/d, 0.70 (0.66-0.75) for 24 g/d, 0.69 (0.64-0.75) for 36 g/d, 0.70 (0.64-0.77) for 60 g/d, 0.74 (0.67-0.83) for 90 g/d, and 0.83 (0.67-1.04) for 135 g/d.
Alcohol consumption in moderation is associated with a reduced risk of CAD with 36 grams/d of alcohol conferring a lower risk than other levels, they conclude.
Source: Alcohol consumption and risk of coronary artery disease: a dose-response meta-analysis of prospective studies. Yang Y; Liu DC; Wang QM; Long QQ; Zhao S; Zhang Z; Ma Y; Wang ZM; Chen LL; Wang LS. Nutrition, published early online 19 December 2015.