In developed countries, sclerotic and calcific degeneration of the aortic valve is a common disorder showing pathophysiologic similarities with atherothrombotic coronary disease. Light to moderate alcohol consumption has been associated with a lower risk for atherothrombotic coronary disease and mortality. Whether alcohol consumption affects the development of aortic valve sclerosis (AVS) is not well known. In the present study, researchers analysed the cross-sectional association between average daily alcohol consumption and AVS in the general population.
Cross-sectional data was analysed from 2,022 men and women, aged 45 to 81 years, from the population-based Study of Health in Pomerania. A computer-assisted interview that included beveragespecific questions about quantity and frequency of alcohol over the last 30 days to calculate the average quantity of alcohol consumption (in grams of ethanol per day) was used. AVS was ascertained by echocardiography. The prevalence of AVS was 32.3%. Average daily alcohol intake displayed a J-type relation with AVS (fully adjusted P value: 0.005). Compared with individuals with an average consumption of 10 g of alcohol per day, multivariable-adjusted odds ratios were 1.60 (95% confidence interval, 1.19-2.14) among current abstainers and 1.56 (95% confidence interval, 1.01-2.41) among individuals with an average consumption of 60 g per day.
The findings indicate that light to moderate alcohol consumption was associated with a lower odds of having AVS. The authors suggest that Prospective data need to address whether alcohol consumption and related changes over time in several biological markers affect the progression of AVS.
Source: Light to moderate alcohol consumption is associated with lower risk of aortic valve sclerosis: the Study of Health in Pomerania (SHIP). Markus MR; Lieb W; Stritzke J; Siewert U; Troitzsch P; Koch M; Dorr M; Felix SB; Volzke H; Schunkert H; Baumeister SE. Arteriosclerosis Thrombosis and Vascular Biology. Published early online 12 March 2015.