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Association of drinking pattern with risk of coronary heart disease incidence in the middle-aged and older Chinese men

Epidemiologic studies have found that moderate alcohol consumption was associated with a decreased risk of coronary heart disease (CHD) incidence, but it is uncertain whether drinking pattern is associated with CHD incidence.

A study investigated the association between drinking pattern and coronary heart disease in 8,469 Chinese men aged 45–81 years from Dongfeng- Tongji cohort. A questionnaire was used to collect information on alcohol consumption and other covariates. Cox proportional hazard regression model was applied to estimate the multivariable-adjusted hazard rations (HRs) and 95% confidence intervals (95% CIs).

Subjects were free of CHD, stroke, or cancer at baseline. During an average of 4.36 years of follow-up, 959 incident CHD events were identified. Compared with non-drinkers, the multivariable-adjusted HR (95% CI) of CHD incidence was 0.84 (0.71–0.98) in current drinkers. With respect to drinking pattern, men who consumed 20.01–40 grams ethanol on a drinking occasion had a 24% lower risk of incident CHD (HR = 0.76, 95% CI = 0.62, 0.94) compared with non-drinkers. The adjusted HRs (95% CI) of CHD incidence were 0.80 (0.65, 0.99), 1.02 (0.84, 1.22), and 0.75 (0.59–0.96) in subjects who consumed 0.01–10, 10.01–30, and > 30 grams ethanol per day, respectively. Participants who consumed 20.01–40 grams ethanol per occasion less than 5 times per week had the lowest risk of CHD incidence (HR = 0.73, 95% CI = 0.52, 0.96). No significant associations were observed between type or frequency of alcohol consumption and CHD incidence.

Drinking was associated with a lower risk of CHD incidence in middle-aged and older Chinese men and a moderate quantity of ethanol per drinking occasion with lower frequency could been considered as a healthy drinking pattern, which might modify the relationship between alcohol consumption and incident CHD, the authors suggest.

Source: Zhang Y, Yu Y, Yuan Y, Yu K, Yang H, Li X, et al. (2017) Association of drinking pattern with risk of coronary heart disease incidence in the middle-aged and older Chinese men: Results from the Dongfeng-Tongji cohort. PLoS ONE 12(5): e0178070. https://doi.org/10.1371/journal. pone.0178070.

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