Page last updated: August 15, 2018
Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study

The association between alcohol consumption and non-fatal and fatal coronary heart disease (CHD) and stroke was investigated in a Multicentre case-cohort study published in the BMJ.

The study used data from the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD). 32 549 participants without baseline CVD were included in the study from eight European countries.

During follow-up there were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated with non-fatal CHD, with a hazard ratio of 0.94 per 12 g/day higher intake. There was a J shaped association between baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83, 0.65, and 0.82 for categories 5.0- 14.9 g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake, respectively, compared with 0.1-4.9 g/day.

In contrast, hazard ratios for non-fatal and fatal stroke risk were 1.04 and 1.05 per 12 g/day increase in baseline alcohol intake, respectively, including broadly similar findings for ischaemic and haemorrhagic stroke. Associations with cardiovascular outcomes were broadly similar with average lifetime alcohol consumption as for baseline alcohol intake, and across the eight countries studied. There was no strong evidence for interactions of alcohol consumption with smoking status on the risk of CVD events.

Source: Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD casecohort study BMJ 2018; 361

doi.org/10.1136/bmj.k934
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