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Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study

Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression The association between alcohol consumption and subclinical atherosclerosis is still unclear. Using data from a European multicentre study, researchers assessed subclinical atherosclerosis and its 30-month progression by carotid intimamedia thickness (C-IMT) measurements, and correlated this information with self-reported data on alcohol consumption.

Between 2002–2004, 1,772 men and 1,931 women aged 54–79 years with at least three risk factors for cardiovascular disease (CVD) were recruited in Italy, France, Netherlands, Sweden, and Finland. Self-reported alcohol consumption, assessed at baseline, was categorised as follows: none (0 g/d), very-low (0 − 5 g/d), low (> 5 to ≤ 10 g/d), moderate (> 10 to ≤ 20 g/d for women, > 10 to ≤ 30 g/d for men) and high (> 20 g/d for women, > 30 g/d for men). Carotid intima-media thickness was measured in millimetres at baseline and after 30 months. Measurements consisted of the mean and maximum values of the common carotids (CC), internal carotid artery (ICA), and bifurcations (Bif ) and whole carotid tree. The associations between Carotid intima-media thickness measures and alcohol consumption categories, adjusting for sex, age, physical activity, education, smoking, diet, and latitude were described.

Adjusted differences between median carotid intima-media thickness values in different levels of alcohol consumption (vs. very-low) showed that moderate alcohol consumption was associated with lower maximum carotid-IMT and mean bifurcation-IMT at baseline and decreasing mean carotid-IMT, mean bifurcation-IMT, and mean and maximum internal carotid artery-IMT after 30 months. In this European population at high risk of CVD, findings show an inverse, or protective relation between moderate alcohol consumption and carotid subclinical atherosclerosis and its 30-month progression, independently of several potential confounders.

Source: Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study. Laguzzi, F., Baldassarre, D., Veglia, F. et al. Eur J Nutr (2020).

doi.org/10.1007/s00394-020-02220-5
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