Page last updated: October 22, 2014
Moderate wine consumption is associated with lower hemostatic and inflammatory risk factors over 8 years

Moderate wine consumption has been associated with reduced cardiovascular (CV) risk, but most investigations have been conducted in Caucasian populations. To investigate the relationship of wine consumption to CV risk markers, researchers studied a multi-ethnic sample of middle-aged, healthy women (N = 2900; 48% white, 28% black, 7% Hispanic, 8% Chinese, 9% Japanese) participating in the Study of Women’s Health Across the Nation (SWAN) over 7 years with repeated assessments of CV risk factors.

Consumption of wine was stable and common with 20% reporting none, 69% light (< 1/day), 7% moderate (= 1/day), and 4% heavy (>1/day). To guard against underreporting, the researchers took the maximum reported wine consumption over 7 years as the predictor.

The relationship between wine consumption and CV risk factors was assessed with moderate consumption as the reference. Longitudinal models were adjusted for ethnicity, age, and time-varying menopausal status, hormone therapy use, overall alcohol consumption, high density lipoprotein (HDL), statin use, and a healthy lifestyle score based on physical activity, not smoking, and weight maintenance.

Interactions of wine consumption with time were not significant. Moderate wine consumers had significantly lower levels of C-reactive protein (CRP, p < .001), fibrinogen (p < .001), factor VII (p < .01), and plasminogen activator inhibitor (PAI-1, p < .05) than women who drank no or little wine. These associations were independent of significant effects of healthy lifestyle and overall alcohol consumption and similar across ethnic groups. Moderate wine consumption may protect against CVD via inflammatory and clotting pathways, the researchers conclude.

Source: Janssen I; Landay AL; Ruppert K; Powell LH, Nutrition and Aging Vol 2, No 2-3, 2014, pp91-99 Paper presented at the WineHealth 2013 International Wine and Health Conference, held 18-20 July 2013 in Sydney, Australia.

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