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The protective role of low-concentration alcohol in high-fructose induced adverse cardiovascular events in mice

Cardiovascular disease remains a worldwide public health issue. As fructose consumption is dramatically increasing, it has been demonstrated that a fructoserich intake would increase the risk of cardiovascular disease. In addition, emerging evidences suggest that low concentration alcohol intake may exert a protective effect on cardiovascular system.

A study investigated whether low-concentration alcohol consumption would prevent the adverse effects on cardiovascular events induced by high fructose in mice. From the results of hematoxylineosin staining, echocardiography, heart weight/ body weight ratio and the expression of hypertrophic marker ANP, the researchers found that high-fructose resulted in myocardial hypertrophy and the lowconcentration alcohol consumption would prevent the cardiomyocyte hypertrophy from happening.

In addition, they observed low-concentration alcohol consumption could inhibit mitochondria swollen induced by high-fructose. The elevated levels of glucose, triglyceride, total cholesterol in high-fructose group were reduced by low concentration alcohol. Low expression levels of SIRT1 and PPAR-γ induced by high-fructose were significantly elevated when fed with low-concentration alcohol. The histone lysine 9 acetylation (acH3K9) level was decreased in PPAR-γ promoter in high-fructose group but elevated when intake with low concentration alcohol. The binding levels of histone deacetylase SIRT1 were increased in the same region in high-fructose group, while the low concentration alcohol can prevent the increased binding levels.

Overall, the study indicates that low concentration alcohol consumption could inhibit high-fructose related myocardial hypertrophy, cardiac mitochondria damaged and disorders of glucose-lipid metabolism. Furthermore, these findings also provide new insights into histone acetylation-deacetylation mechanisms of low-concentration alcohol treatment that may contribute to the prevention of cardiovascular disease induced by high-fructose intake.

Source: The protective role of low-concentration alcohol in high-fructose induced adverse cardiovascular events in mice. Wu X, Pan B, Wang Y, Liu L, Huang X, Tian J. Biochem Biophys Res Commun. 2017 Nov 22. pii: S0006- 291X(17)32320-3. doi: 10.1016/j.bbrc.2017.11.141.

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