The association between alcohol consumption and venous thromboembolism (VTE) risk has been investigated by various observational studies with inconsistent results. Researchers in China examined this association by performing a meta-analysis of prospective studies.
A comprehensive literature search was carried out in the PubMed, EMBASE, and Web of Science from its inception to February 2020. Pooled effect estimates were calculated using a random effect model. Ten prospective studies (14 cohorts) were included in this meta-analysis with a total of 441,128 individuals and 10,221 VTE cases.
Overall, the highest consumption of alcohol was not associated with the VTE risk compared with the lowest group [relative risk (RR), 0.96 (95% CI, 0.89–1.04). and no obvious heterogeneity of RRs was observed across these studies
In the subgroup analysis by sex, a borderline significant association between alcohol consumption and VTE risk was observed in women [RR, 0.91 (95% CI, 0.82–1.00)]. In the dose–response analysis, a linear decrease in VTE risk with increasing alcohol intake was observed. However, the reduced risk was not statistically significant.
The results from this meta-analysis suggest that alcohol intake is not related with the risk of VTE. Further large well-designed cohort studies are warranted to investigate a potential protective role of alcohol against VTE in women the researchers say.
Source: Chen, M., Ji, M., Chen, T., Hong, X., & Jia, Y. (2020). Alcohol Consumption and Risk for Venous Thromboembolism: A Meta-Analysis of Prospective Studies. Frontiers in nutrition, 7, 32.