Page last updated: April 22, 2013
Is ADH1C genotype relevant for the cardio protective effect of alcohol?

Authors of a recent study state that the cardio protective effect of ethanol has been suggested to be linked to one of the ethanol metabolising enzymes (ADH1C), which constitutes a high Vmax and a low Vmax variant. This has been demonstrated in some studies, while others have not been able to replicate the findings. The aim of the present study was to investigate the relation between the different ADH1C genotypes, death from coronary heart disease (CHD) and alcohol in a material larger than the previously published studies.

Eight hundred CHD deaths as well as 1303 controls were genotyped for the high Vmax (    1) and the low Vmax (   2) ADH1C variant. Information of alcohol use was available for all subjects. Multiple logistic regression analyses was used to study if the decreased risk of death from CHD in alcohol consuming subjects was more pronounced in subjects homozygous for the     2 allele (    2   2 subjects) compared to   1  1 and    1   2 subjects.

The study found that the reduced odds ratio (OR) for death from CHD in alcohol consumers compared to abstainers was similar in the genotype groups, i.e., 0.62 (95% CI: 0.43–0.88) in  1  1 subjects and 0.62 (95% CI: 0.42–0.91) in   2  2 subjects. Also when stratifying the results by gender and when dividing alcohol consumers into different alcohol consumption groups, there was no difference in the OR between the different genotype groups. This study, which included the largest study group published so far, failed to find any link between the ADH1C genotype and the cardio protective effects of alcohol.

Source: Is ADH1C genotype relevant for the cardioprotective effect of alcohol? Alcohol, G Høiseth, P Magnus, GP Knudsen, MD Jansen, Ø Næss, K Tambs, J Mørland, Alcohol. Published online 14 January 2013.

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