Triglycerides-to-high-density-lipoprotein cholesterol ratio (TG/HDL-C ratio) has been proposed to be a useful predictor of cardiovascular disease. Habitual alcohol drinking causes elevation of triglycerides and HDL cholesterol levels. A study by Ichiro Wakabayashi sought to determine how the TG/HDL-C ratio is influenced by alcohol intake. The study subjects were 21,572 Japanese men (age range: 35–60 years) who were divided into non-, light (<22 g ethanol/day), heavy (≥22 but <44 g ethanol/day), and very heavy (≥44 g ethanol/day) drinkers. The relationship between alcohol intake and TG/HDL-C ratio was investigated by using analysis of covariance and logistic regression analysis. The log-transformed TG/HDL-C ratio was significantly lower in light, heavy, and very heavy drinkers than in nondrinkers and was lowest in light drinkers. Odds ratios for high TG/HDL-C ratios in light and heavy drinkers versus nondrinkers were significantly lower than a reference level of 1.00 (light drinkers: 0.63, 95% CI [0.57, 0.71], p < .01); heavy drinkers: 0.75, 95% CI [0.69, 0.81], p < .01]). Odds ratios for high waist-to-height ratio of subjects with versus subjects without high TG/HDL-C ratios were significantly higher than the reference level in non-, light, heavy, and very heavy drinkers and were significantly lower in heavy and very heavy drinkers than in nondrinkers (nondrinkers: 3.84 [3.42,4.31]; light drinkers: 3.65 [2.97,4.48]; heavy drinkers: 3.17 [2.84, 3.54], p < .05 compared with nondrinkers; very heavy drinkers: 2.61 [2.29, 2.97], p < .01 compared with nondrinkers). Ichiro Wakabayashi concludes that alcohol drinking is inversely associated with TG/ HDL-C ratio and confounds the relationship between TG/HDL-C ratio and obesity. Source: Inverse Association Between Triglycerides-to-HDL-Cholesterol Ratio and Alcohol Drinking in Middle-Aged Japanese Men. Ichiro Wakabayashi. Alcohol and Drugs Volume 73, 2012 > Issue 6: November 2012.