Page last updated: Monday, February 09, 2009
Drinking patterns and myocardial infarction: a linear dose response model
The relation of alcohol intake to cardiovascular health is complex, involving both protective and harmful effects, depending on the amount and pattern of consumption.

The study results indicate that MI (heart attack) risk decreased with increasing frequency of drinking, but increased as drinking dosage increased. Rates of increasing MI risk associated with drinking dosage were twice as high among women as they were among men. Relative to controls, lower MI risk was associated with consuming < 4.55 drinks per drinking day for men (95% CI: 2.77 to 7.18) and < 3.08 drinks per drinking day for women (95% CI: 1.35 to 5.16), increasing after these cross-over points were exceeded.

This study offers further evidence of the protective effects of moderate drinking – little and often as protective against heart attack risk in adults. Confirming the well established J shape curve, any protective effect is negated once consumers drink more than three (women) to four drinks (men) a day. Use of a well-specified mathematical dose–response model provided precise estimates for the first time of how drinking frequency and dosage each contribute linearly to the overall impact of a given drinking pattern on MI risk in men and women.

Drinking Patterns and Myocardial Infarction: A Linear Dose-Response Model. Autores: Russell M,Chu BC,Banerjee A,Fan AZ,Trevisan M,Dorn JM,Gruenewald P: Alcohol Clin Exp Research.

no website link
All text and images © 2003 Alcohol In Moderation.