A pooled analysis of six ongoing large-scale cohort studies in Japan estimated the quantitative contribution of alcohol consumption to all-cause and major causes of mortality in the Japanese population.
Source. Impact of alcohol intake on total mortality and mortality from major causes in Japan: a pooled analysis of six large-scale cohort studies. Inoue M, Nagata C, Tsuji I, Sugawara Y, et al J Epidemiol Community Health 2010 Dec 10.
The analysis included 309,082 subjects with 35,801 deaths during a follow-up period ranging from 7 to 18 years. A J- or U-shaped association was found for the risk of total and major causes of mortality in men, and the risk of total and heart disease mortality in women. Compared to non-drinkers, there was a significantly lower risk of total mortality at an alcohol consumption level of <69 g/day, cancer mortality at <46 g/day, heart disease mortality at <69 g/day and cerebro-vascular disease mortality at <46 g/day in men, and for total mortality at <23 g/day in women. At a higher consumption, the mortality risk increased linearly with rising dose of alcoholic beverages among drinkers.
The scientists concluded that keeping the intake of alcoholic beverages below 46 g/day in men and 23 g/day in women appears to minimise the mortality risk in the Japanese population.