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The effect of moderate alcohol consumption on biomarkers of inflammation and hemostatic factors in postmenopausal women

Inflammation and hemostasis contribute to the etiology of cardiovascular disease. A study evaluated the effect of moderate alcohol consumption on biomarkers of inflammation and hemostasis in postmenopausal women. Previous studies by the same research group has demonstrated that moderate alcohol consumption (1–2 drinks/day) may decrease risk for cardiovascular disease because of an improved lipid profile. In addition to these beneficial changes, the alcohol-mediated reduction in risk may be through its effect on inflammation and hemostasis.

As part of a controlled diet study, 53 postmenopausal women each consumed a weight-maintaining diet plus 0, 15 and 30 g/day of alcohol for 8 weeks. The controlled diet contained 15%, 53% and 32% of energy from protein, carbohydrate and fat, respectively.

Soluble intercellular adhesion molecule-1 decreased by 5% (P<0.05) with consumption of both 15 and 30 g of alcohol. Fibrinogen concentrations decreased by 4% and 6% (P<0.05) after consumption of 15 and 30 g alcohol, respectively. Fibrin D-dimer decreased by 24% (P<0.05) after consumption of 30 g of alcohol. Plasminogen activator inhibitor-1 (PAI-1) concentrations were increased 27 and 54% (P<0.05) after consumption of 15 and 30 g of alcohol. Plasma high-sensitivity C-reactive protein, interleukin-6 and factor VII coagulant activity did not change with alcohol consumption.

The authors suggest that moderate alcohol consumption may have beneficial effects on inflammation and hemostasis in postmenopausal women, and this may be somewhat mitigated by an increase in Plasminogen activator inhibitor-1.

Source: The effect of moderate alcohol consumption on biomarkers of inflammation and hemostatic factors in postmenopausal women. K S Stote, R P Tracy, P R Taylor and D J Baer. European Journal of Clinical Nutrition , (11 November 2015).

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