Epidemiologic studies have reported conflicting results regarding maternal alcohol consumption before and during pregnancy, and the risk of congenital heart defects (CHDs). However, a systematic review and meta-analysis of the association between maternal alcohol consumption and CHDs in offspring has not been conducted.
MEDLINE and EMBASE were searched for articles catalogued between their inception and February 16, 2015; The reseachers identified relevant published studies that assessed the association between maternal alcohol consumption and CHD risk. From the 1,527 references, a total of 19 case-control studies and four cohort studies were enrolled in this meta-analysis. The summary of 23 studies related to CHDs indicated an overall pooled relative risk of 1.13 (95% confidence interval: 0.96, 1.29) among mothers drinking before or during pregnancy. In summary, the meta-analysis provided no positive association between maternal alcohol consumption and risk of CHDs.
Source: Maternal Alcohol Consumption before and during Pregnancy and the Risks of Congenital Heart Defects in Offspring: A Systematic Review and Meta-analysis. Sun J, Chen X, Chen H, Ma Z, Zhou J. Congenit Heart Dis. 2015 Jun 1.